Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Impact Factor & Key Scientometrics

I. Basic Journal Info

Country

Netherlands

Journal ISSN: 00275107, 18792871

Publisher: Elsevier BV

History: 1964-2021

Journal Hompage: Link

How to Get Published:

Research Categories

Scope/Description:

Mutation Research MR provides a platform for publishing all aspects of DNA mutations and epimutations from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization from point mutations to genome structural variation chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome i.e. changes in DNA methylation histone modification and small regulatory RNAs.MR publishes articles in the following areasOf special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation stem cell biology and cell fate in general including various forms of cell death and cellular senescence.The study of genome instability in human molecular epidemiology and in relation to complex phenotypes such as human disease is considered a growing area of importance.Mechanisms of epimutation induction for example during DNA repair replication or recombination novel methods of epimutation detection with a focus on ultrahighthroughput sequencing.Landscape of somatic mutations and epimutations in cancer and aging.Role of de novo mutations in human disease and aging mutations in population genomics.Interactions between mutations and epimutations.The role of epimutations in chromatin structure and function.Mitochondrial DNA mutations and their consequences in terms of human disease and aging.Novel ways to generate mutations and epimutations in cell lines and animal models.